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  • BSI
    PD ISO/TR 16379:2014 Tissue-engineered medical products. Evaluation of anisotropic structure of articular cartilage using DT (Diffusion Tensor)-MR Imaging
    Edition: 2014
    $418.55
    / user per year

Description of PD ISO/TR 16379:2014 2014

This Technical Report has been prepared for evaluation of therapeutic courses for articular cartilage disease and summarizes results from structural evaluation of knee joint cartilage by diffusion tensor imaging, an MRI applied technology allowing non-invasive observation of soft tissue morphology in vivo.

This Technical Report is intended for use in areas such as regenerative medicine for knee joint cartilage disease.

After in vivo transplant of cartilage cells or tissue as a regenerative treatment, longitudinal diagnosis is needed to assess regeneration as articular cartilage, but arthroscopes used primarily for this purpose are invasive and also do not allow evaluation of structure by simple observation of surfacial characteristics. Radiography and CT do not visualize articular cartilage and also entail the problem of exposure. Collagen fibres, the primary component of articular cartilage, have a surfacial layer parallel to the articular surface to serve a lubricating function for the articular surface, a middle layer with a randomized structure to distribute loads, and deep layers oriented vertically to support loads. The anisotropy of this three-layer structure is a characteristic feature of hyaline cartilage structures and a mechanism demonstrating a lubricating function for articular cartilage. We can then ask whether articular cartilage can be assessed by evaluating the anisotropy of collagen.

MRI techniques allow non-invasive visualization of soft tissue form and function in vivo, and DT-MRI conveys the direction of water molecule motion. In fibrous tissues, the direction of water molecule motion is restricted to the direction of fibre orientation; consequently, the direction of water molecule motion matches that of fibre orientation. The use of DT-MRI therefore does allow evaluation of collagen fibre orientation and anisotropy in articular cartilage.

DT-MRI is thus used to observe articular cartilage anisotropy data for use as standardized data in longitudinal diagnosis following transplant of articular cartilage as a regenerative treatment.



Standard NumberPD ISO/TR 16379:2014
TitleTissue-engineered medical products. Evaluation of anisotropic structure of articular cartilage using DT (Diffusion Tensor)-MR Imaging
StatusDefinitive
Publication Date2014-05-31
Identical National Standard OfISO/TR 16379:2014
DescriptorsAnisotropy, Mathematical calculations, Products, Joints (anatomy), Therapeutics, Diffusion, Structures, Electrical medical equipment, Knees, Histology, Medical equipment
ICS11.040.40 Implants for surgery, prosthetics and orthotics
CommitteeBTI/1
ISBN978 0 580 82564 4
PublisherBSI
Pages34

About BSI

BSI Group, also known as the British Standards Institution is the national standards body of the United Kingdom. BSI produces technical standards on a wide range of products and services and also supplies certification and standards-related services to businesses.
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