ASTM F750-87(2002)e1
Historical Standard: ASTM F750-87(2002)e1 Standard Practice for Evaluating Material Extracts by Systemic Injection in the Mouse
SUPERSEDED (see Active link, below)
ASTM F750
1. Scope
1.1 This practice covers a nonspecific, acute toxicity test used for detecting leachables from materials used in medical devices.
1.2 The liquids injected in the mouse are those obtained by Practice F 619 where the extraction vehicles are saline, vegetable oil, or other liquids simulating human body fluids.
1.3 Two procedures are outlined: Method A for intravenous injection and Method B for intraperitoneal injection.
1.4 This practice is one of several developed for the assessment of the biocompatibility of materials. Practice F 748 may provide guidance for the selection of appropriate methods for testing materials for a specific application.
2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.
ASTM Standards
F619 Practice for Extraction of Medical Plastics
F748 Practice for Selecting Generic Biological Test Methods for Materials and Devices
Keywords
acute toxicity tests; biocompatibility; intravenous injection; intraperitoneal injections; mouse/mice; test animals ;
ICS Code
ICS Number Code 11.220 (Veterinary medicine)
DOI: 10.1520/F0750-87R02E01
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